83 888程目昌811含1111881川 9gs s =8838 88911898811119811 互年留女 中5P82 晨P型品 g将N日口下8下草四 2 Fy口N口o其早wN四-o寸me 月目时 888 le 华兽侣合±只合合吉兰g合普吕 吉莒吉吉 9= 多留西8时6导品网忍高子时0=88用石四上型高8 m oOO N I N OO NN OO-N O69 8 9g6g- 品铝6品6导品房& TABLE II. Exposed Cases and Controls,ORs,95% CI for all Leukemia, Acute Myeloid Leukemia,Chronic Lymphatic Leukemia and Multiple Myeloma by Chemical and Intensity of Exposure
Italian Case-Control Study ICD:IX Exposure intensity level Leukemia (ICDIX: 204^208) Acute myeloid leukemia (ICDIX: 205.0) Chronic lymphatic leukemia (ICDIX: 204.1) Multiple myeloma (ICDIX: 203) No. of cases No. of controls ORa 95% CI No. of cases No. of controls ORa 95% CI No. of cases No. of controls ORa 95% CI No. of cases No. of controls ORa 95% CI Unexposedb 355 811 1.0 133 811 1.0 103 925 1.0 163 674 1.0 Chemical class Solvents Very low/low 43 86 1.0 0.7^1.5 18 86 1.3 0.7^2.3 12 113 0.7 0.4^1.5 19 74 1.3 0.7^2.3 Medium/high 82 166 0.9 0.6^1.2 24 166 0.8 0.5^1.3 35 208 1.0 0.6^1.6 31 151 0.9 0.5^1.4 Aromatic hydrocarbons Very low/low 19 51 0.7 0.4^1.2 6 51 0.6 0.3^1.6 7 79 0.6 0.3^1.4 10 47 1.0 0.5^2.2 Medium/high 50 95 0.9 0.6^1.3 13 95 0.7 0.4^1.6 27 121 1.3 0.8^2.2 23 88 1.2 0.7^2.0 Chlorinated hydrocarbons Very low/low 26 52 1 0.6^1.6 13 52 1.4 0.7^2.8 6 68 0.6 0.3^1.6 13 47 1.5 0.8^3.0 Medium/high 37 67 0.9 0.6^1.4 13 67 1.0 0.5^1.8 17 90 1.1 0.6^2.0 16 62 1.1 0.6^2.1 Technical hydrocarbons Very low/low 18 40 0.8 0.4^1.5 5 40 0.7 0.3^1.8 7 50 0.8 0.3^2.0 5 37 0.6 0.2^1.7 Medium/high 52 95 0.9 0.6^1.3 14 95 0.7 0.4^1.4 29 125 1.1 0.7^1.9 22 92 0.9 0.5^1.7 Aliphatic hydrocarbons Very low/low 13 33 0.8 0.4^1.6 2 33 0.4 0.1^1.6 7 53 1.0 0.4^2.4 3 28 0.5 0.1^1.7 Medium/high 19 74 0.5 0.3^0.8 7 74 0.5 0.2^1.2 14 104 0.9 0.5^1.7 11 68 0.7 0.3^1.4 Derivative-oxygenate hydrocarbons Very low/low 17 29 1.2 0.6^2.3 4 29 0.9 0.3^2.7 8 52 1.3 0.5^3.0 6 23 1.8 0.7^5.0 Medium/high 34 84 0.8 0.5^1.2 10 84 0.7 0.3^1.3 19 107 1.1 0.6^2.1 14 76 0.9 0.5^1.7 Individual chemicals Benzene Very low/low 16 50 0.5 0.3^0.9 3 50 0.3 0.1^1.0 11 77 0.7 0.3^1.4 8 47 0.6 0.3^1.5 Medium/high 25 32 1.3 0.7^2.3 6 32 0.9 0.4^2.3 12 35 1.8 0.9^3.9 14 29 1.9 0.9^3.9 Styrene Very low/low 1 8
0 8 0 16 2 7

Medium/high 2 11
0 11 2 12 2 9

Xylene Very low/low 20 64 0.5 0.3^0.9 5 64 0.4 0.2^1.1 15 99 0.9 0.5^1.8 9 59 0.6 0.3^1.4 Medium/high 10 27 0.7 0.3^1.5 2 27 0.4 0.1^1.8 9 34 1.9 0.8^4.5 6 23 1.2 0.4^3.2 Toluene Very low/low 21 66 0.5 0.3^0.9 5 66 0.4 0.2^1.0 14 99 0.9 0.4^1.6 10 61 0.6 0.3^1.3 Medium/high 13 28 0.9 0.4^1.7 2 28 0.4 0.1^1.7 10 35 2.1 0.9^4.7 5 24 0.9 0.3^2.7 Dichloromethane Very low/low 7 21 0.7 0.3^1.7 3 21 2 28 0.4 0.1^2.0 4 20

Medium/high 2 8 0.5 0.1^2.3 0 8 2 8 1.6 0.3^8.6 0 8

Tetrachloroethylene Very low/low 6 17 0.6 0.2^1.6 2 17 3 29 3 15

Medium/high 7 12 1.0 0.4^2.7 2 12 1 15 2 12

Trichloroethylene Very low/low 17 34 1.0 0.5^1.8 6 34 1.0 0.4^2.5 8 47 1.2 0.5^2.7 9 28 1.5 0.7^3.5 Medium/high 11 29 0.7 0.4^1.5 6 29 1.1 0.5^2.9 4 35 0.9 0.3^2.6 5 27 0.9 0.3^2.4 1,1,1-Trichloroethane Very low/low 5 12 0.7 0.2^2.0 1 12 3 23 2 10

Medium/high 5 7 1.4 0.4^4.7 2 7 0 9 1 5

aAdjusted by gender, age, education and area, ORs shown for at least five exposed cases. bReference group: subjects who never used any chemical (OR ¼1). 5