LETTER RESEARCH 6 PM TM6 TM5 自 TM5 942 TM5 TM6 VSD G TM6 久A广 TM6 13.5 green, chain A cvan chain B 吧 TM6 TM5 purple,chain C chain D TM5 -verapamil in the pore Limited,Letter RESEARCH Extended Data Figure 9 | Br-verapamil binding breaks symmetry. a, Alignment of the 4 subunits of CaVAb in complex with Br-verapamil showing the voltage sensor module (VSD) and the ends of S6 are different. b, Measuring the Cα distances between T206 residues in adjacent subunits shows that the channel is indeed asymmetrical with Br-verapamil in the pore. © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved