le Org Appropriate Dose Metric Enhanced and New Testing Approaches ·Short Term Goal -Make existing animal testing paradigm more efficient, reliable&responsive to our rrisk assessment management needs FQPA Issues(lifestage susceptibilites,mechanisms of toxicity, ILSI-HESI Proposed Tiered Approach -Important Springboard .Reduces animal usage by optimizing study designs takes risk assessment needs&exposure characteristics into account More Foundation Consensus Building Needed Retrospective prospective analyses 77 13 Appropriate Dose Metric Response Endpoint Subcellular Cell Tissue Chronic Whole Organism Acute Whole Organism 14 • Short Term Goal – Make existing animal testing paradigm more efficient, reliable & responsive to our risk assessment & management needs • FQPA Issues (lifestage susceptibilites, mechanisms of toxicity, etc) • ILSI-HESI Proposed Tiered Approach – Important Springboard • Reduces animal usage by optimizing study designs & takes risk assessment needs & exposure characteristics into account – More Foundation & Consensus Building Needed • Retrospective & prospective analyses Enhanced and New Testing Approaches