EPA-Pesticide Program Plan for Paradigm Change Analyze and Update Current Data Requirements sed Changes to Regulations on Testing ayei aafor Key Support Development and Use of Enhanced and New Testing Approaches and other Analytic Techniques ILSI/HESI Proposed Tiered Approach Inert Ingredient SAR Analysis Advance Research Agenda -Greater Reliance on Emerging Tools of Computational Toxicology Retrospective Analyses of Pesticide Database ·Ongoing Reviews -Dog Toxicity Studies -Rodent Cancer Studies -Rat Multi-generation Reproductive Studies -Rat Neurodevelopmental Toxicity Studies Incorporate Lessons Learned into Regulatory Practice 6 11 EPA – Pesticide Program Plan for Paradigm Change • Analyze and Update Current Data Requirements – Proposed Changes to Regulations on Testing Requirement – Retrospective Analyses of Pesticide Data for Key Endpoints • Support Development and Use of Enhanced and New Testing Approaches and other Analytic Techniques – ILSI/HESI Proposed Tiered Approach – Inert Ingredient SAR Analysis • Advance Research Agenda – Greater Reliance on Emerging Tools of Computational Toxicology 12 Retrospective Analyses of Pesticide Database • Ongoing Reviews – Dog Toxicity Studies – Rodent Cancer Studies – Rat Multi-generation Reproductive Studies – Rat Neurodevelopmental Toxicity Studies • Incorporate Lessons Learned into Regulatory Practice