Current Paradigm Risk Managers Focus on Potential Adverse Outcomes Mortality Reproductive Developmental Fertility BATTERY of Animal Testing (Part 158) Current Toxicology Testing Paradigm Generates In Vivo Animal Data for all Possible Outcomes to Determine which of all Possible Effects are Relevant Implementing Change Development and implementation of a new,integrated approach to the testing and assessment of pesticides will be a challenge and will take place over the next 10 years .Scientific tools and knowledge must be 8iae86R8beee6eegdngana National Academy of Science study 、分5 9 Mortality •Systemic Toxicity •Disease •Cancer Reproductive Fitness •Viable Offspring •Fertility Developmental Impairment •Terato •Prenatal Deficits Current Paradigm • Risk Managers Focus on Potential Adverse Outcomes • Current Toxicology Testing Paradigm Generates In Vivo Animal Data for all Possible Outcomes to Determine which of all Possible Effects are Relevant BATTERY of Animal Testing (Part 158) 10 Implementing Change • Development and implementation of a new, integrated approach to the testing and assessment of pesticides will be a challenge and will take place over the next 10 years • Scientific tools and knowledge must be advanced and public understanding and confidence must be developed • National Academy of Science study