聚酮合酶催化合成红霉素 DEBS1 DEBS2 DEBS3 功能单元1 功能单元2 功能单元3 功能单元4 功能单元5 功能单元6 AT ACP KS AT KR ACP KS AT KR ACP KS AT ACP KS AT DH ER KR ACP KS AT KR ACP KS AT KR ACP TE 13 0 0 HO HO HO 0 H3C. .CH3 9 OH H3C. -OH CH3 1 N(CH3)2 HO HO H3C、 CH3 H3C H3C. CH3 12OH6 OCH3 HO H3C CH3 OH OH CH3 CH3 OH CH3 红霉素A 6-Deoxyerythronolide B 聚酮合酶催化合成红霉素 AT ACP KS AT KR ACP KS AT KR ACP KS AT ACP KS AT DH ER KR ACP KS AT KR ACP KS AT KR ACP TE S O S O HO S O HO HO S O HO HO O S O HO O HO S O HO HO HO O S O HO HO O HO HO 13 13 13 13 13 13 13 13 9 9 9 9 9 9 5 1 5 5 功能单元1 功能单元2 功能单元3 功能单元4 功能单元5 功能单元6 DEBS1 DEBS2 DEBS3 红霉素A 6-Deoxyerythronolide B O O CH3 HO OH N(CH3)2 H3C O O H3C CH3 H3C O CH3 O O CH3 CH3 OH OCH3 CH3 OH HO H3C OH H3C O O H3C CH3 H3C O CH3 OH OH CH3 HO H3C 9 1 3 6 12 9 12 5 5 6 3