Middle-East J.Set.Res.5():514-5192010 oharmacologists ete The invention of the acalung and DIBROMO-6(3.4 tribromo pyrrole-2vl)Phenol:Highly the advent of new technology in the past few decades led brominated pyrrole phenol possessing antibiotic to the awareness that the oceans may be a new frontier properties,from marine Pseudomonas bromoutilis of biomedical research and key to cure of many dreaded Cephalosporins:Discovered in the 50's from a marine diseases number of natu ospon has le to es rapidl 5,6A new comp aced fro 1 Drugs from marine sp s:Microbiologists are highly ges ascidians hrvo ans and molluscs and some them are cuenty in clinical trials [7].Research into the enormous amounts of microorganisms.They can be pharmacological properties of marine natural products has considered asmicrobial fermenters'that hold a largely led to the discovery of many potently active agents untapped potential for therapeutics.Sponges are considered worthy of clinical application.The marine traditionally a rich source of bioactive compounds in a environment variety logical screens [I]and a numbe are in develop cts [8]Th ted lac is tha of the Caribbe ytotoxic evelic and linear p tides dolastatins Due 286 a analoe of hemiasterlin 1 to its potency and mechanism of action.dolastatin 10.a isolated from a south african sponge Hemiasterello linear dersipeptide which was shown to be a tubulin minor [12]and soon thereafter from a Papua New Guinea interactive agent.entered Phase I clinical trials in the sponge from Cybastela [13]and a synthetic analog 1990s and progressed through to Phase II trials as a single (E7389)of halichondrin B [14].which was originally agent,but has lack of significan As ey from ten th TZT-1027 (Auistatin PE d fr linical trials in e nd the Inited sto T9] uth isla The modem concent for the treatment of buman ailn ssa cantharella and.389 a synthetic omprises natural roducts with unusual structures and analog of bengamide a isolated from jaspis of coraciac functions derived from marine plants and animals.The advanced into clinical trials,but was dropped due to lack arious biodvnamic agents isolated from marine origin of efficacy [6,9].Avarol and Avarone Isolated from been developed in recent years.Some of the sponge. Diced avara.inhibit immunodeficiency virus. orin,Cytosine,S nigh therapeutic indices and the to cros etc.,are y.T BOL 2. drugs rful 14 and pon n killer Sno Drues from Marine Micro Oreanism and from carribean (West indies)s rynta has Phytopplankton:Numerous bioactive compounds of shown promising anti-tumor and antiviral activities invertebrate origin are in fact microbial metabolites Spongouridine Isolated from Carribean (West Indies originating from dietary.commensalic or endosymbiotic sponge,C.crypta has shown promising anti-tumor and microorganisms.Istamycin A and B.Isolated from marin antiviral sponge Streptomyces lenjimariensis against dve an can fight the Al used in the to as [15] 515