Middle-East 1.Sci.Res..5 (6):514-519.2010 and gra ative bac was modelled based on sp 1231.How most fish c-helical p ptides are m or spongouridine.Ara-A is the first spong -derived of the piscidin family,which include the antiviral compound in the market.Polyketide Calyculin A and piseidins [20]Pleurocidins are 25-residue peptides (a selective inhibitor of protein phosphatise 1.isolated first isolated from the skin mucus of winter flounder. Manoalide (a poten id Drugs from Echinoderms:Marine-derived cor ant protein phosphatises and 2 tively isolated from ecteinascidin 743 isolated from the Caribbean ascidian Luffariella variabilis and Halichondria okadai has Ecteinaseidia turbinata [25].aplidine,the dehydro reached the market undergoing from basic research to analoe of didemnin b.isolated from the Caribbean long phases of clinical study [16,17]. solidum [26].Many cytotoxic of th nterest Drugs them ha are the exhibit anti-Hy and antiinfluenza activity [gl kainic Cystodvtes).HOLOTHURINS.Toxie tri Acid a valuable antibelmintic used clinically in japan terpenoid elvcosides.obtained from sea cucumbers against parasitic roundworm,tapeworm isolated from Actinopyga agassizi are found to inhibit the growth of namely Digene Dom sarcoma and aden sola B,ha ve been - Sulfatad found to non-immune inflammatory response eg. rat paw odema,has also Drugs from Corals:Prostaglandins.(1 5-epi-PGA2 acetate been injected into sinovia l fluid of animals to produce 15 S PGA2)The richest natural source of anti-inflammatory drugs. Nere toxin,A mumbe prostag landins,s far discovered in the soft coral alogenated ated from I ine red algae in the n se ri lich ides PGE2 which s.has plant growth similar to indole auxins sp.Bugula neritina and soft coral compounds,diterpene elycoside 'Eleutherobin'and Pyrrole alkaloid alkaloid Drugs from Fish:Squalamine,isolated from the com Lamellarin D while. anti-inflammatory collecte off th 'OAS-10 whic c de opterisone A are the hope of new effective m Drugs from Molluses:Kahalalide F.isolated from the addition isolated from liver of puffer fish,po Hawaian mollusk.Elysia rufescens [27,28].spisulosine cardiovascular activity. Alpha-helical amphipathic solated from the marine clam,Spisula polynyma [29 are ery commo in fish as re Dolatriol,Isolated from marine Dollabell antile 11 ad fo Moses sole pardachin tug on the hasis of in trials Alkvlamino alcohol ES-2s (Spisuloaine their cytotoxic,pore-forming activitie [2122].Pardaxins isolated from Mactromeris polynyma is another were originally described as toxins with anti-predatory compound in preclinical trial,molecular target of this function but subsequently they have been found to be molluscan compound is Rho (GTP-bp). 516