Middle-East J.Set.Res.5():514-519.2010 The high potency of cone snail venoms has inspired for human health and welfare but also for marine ecoloo pharmacologists to investigate their potential use as [36].These entities are the sources of new leads for adiuncts in anaesthesia. antiepileptic. cardiac and atment of many dis ease such as cancer, AIDS antipsychotic drugs.More than 100 patents and patent con large variety of vira the st 37. al of Indian wealth way back in late 1560 Such efforts were launched Pharmaceuticals under the pame Prialt and is used for in India only in the last decade with prestigious intratracheal treatment for chronic pain. Lungbya nstitutions (Nationa Centre for Ocean Information majuscule was recognized as the source of aplysia toxin FRI.CDRI.NIO)fiuding found in sea slug Aplysia [30].Similarly,a serves of sed their RD highly active antitumor compounds,dollastains ins olate ing by 00%in tit's group are considered to b the past 4 years [24).however,they still spend only one tenth of their revenues on r&d ainst 20%by western sed on the potentially large health benefit Drugs from Annelids:Three novel AMPs have been 0 an purified from marine worms.Two isoforms of the AMP. arenicin.have been purified from the immunecells of the e biomedical tha lueworm.Arenicola marina [31].Th dhRph and the all-too-obvious limitations of our laboratories [38] ing (31 In conclusion study of marine organisms tor ther kill E pote an imp ich and vas permeabilization [32].A second annelid peptide,named Indian coast in the form estuaries creeks deep seas and perinerin,has be ified from the clamworm.Perinereis aibuhitensis [33].Finally.the most recent AMP to be continental shelf is potential useful for research in the ated fr stin purified fro area of marine drug development and exciting new frontier of scientific discovery and economic opportumty es n hedistins ACKNOWLEDGEMENT active gainst Gram and Gram negative bacteria. Authors thank the University Grants Commission Go of Ind for the h Drugs from Other Organism:Bryostatins,A group of ank the aut Pondicherry macrolide known as bryostatins,isolated from Buguld nerie mall-cal REFERENCES Skeleto bronchopulmonary carcinoma line NSCLCN6)[35]. Saclike filter feeder tunicates have been reported to be an Mo Ce .R.E.Longley and FE. Koehn 19 The importent source in drug t Boston.V.P.Gullo.(Eds.).pp 109.174 2. Carte.B.K1996.Biomedical Potential of Marine om 1 Natural Products.Biosciences,pp:271-286 tide Vitile D 3. Newman.D. M.Snader,2000 amide'from Diason ata are G.M.Cragg and a few tunicate compounds in anticancer preclinical or 4 Mar lit Vor arine literatu clinical trials datahase produced and maintained hy the Study of marine organisms is a discipline,which Department of Chemistry,University of Canterbury endeavours to identify and de cipher the trout New Zealand (www.chem.canterbury.ac.nz/marinlit regarding not only sustainable exploitation of marine life marinlit.shtml). 517