06-Antibody microarray Antibody microarray From Wikipedia cyclo An antibo Cmmartayaokaonasantiodyarayj Ameoymecreaeanddeted solid surface such as glass,plastic,membrane,or silicon chip,and the interaction between the antibody and its target d a Contents 3Applications rray creations and 4 References Background vere first introduced by Tse Wen Chang in 1983 in a working at Centocor in Malvem Pennsylvania.Chang coined the term"antibody matrix"and discussed"aray"arrangement of minute antibody spots on small glass or plastic surtaces.He demonstrated that a I x10 (100 in total)and 20x20 (400 in total) dy spo mated tha I anan 025mm diameter.Chang's invention focused on the employment of antibody microarrays for the detection and quantification of cells bearing certain surface antigens,such as CD antigens and HLA allotypic antigens, particulate anti such as viruses and bacteria,and soluble antigens. The principle of o esample ons,assay con nd me scribed and Nap T Chang were setti n Texas in 1986 chased the ights on the antibody matrix patents from Centocor as part of the technology base to build their new startup.Their first product in development was an assay,termed "immunosorbent cytometry",which could be employed to HmianaiWis,ie,theconcentaiosandaiasotcD3,cD,andcDerTcls.inhebodoi nd cllethe aeand binding sy as further developed by Roger Aortio3goeodLanthodmicoamarswouldnotoaly permit simu neous screeningo an analyte panel,but woul a also be mor esensitive and rap f the achievements in genomics by DNA micrparrays and the Human Genome Project The capability,the small surface area in each well limits the number of antibody spots and thus,the number of06-Antibody microarray