1/26/2016 Ciliated cells of the respiratory system infected with Bordetella pertussis Pertussis(Whooping Cough) Stage 1:catarrhal stage,like the common cold Stage 2:paroxysmal stage,mucus accumulates, violent coughing.gasping for air Stage 3:convalescence stage,may last for months Infants do not cope with the coughing and brain damage often occurs as a result Prevented by DTaP vaccine Treated with erythromycin or other 网2m macrolides;must occur before coughing starts Pertussis CDC reported Pertussis cases in the US:1922-2013 Before vaccines,6000 people died annually in the United States from Whole c pertussis Today the acellular pertussis vaccine (DTaP)is given 6 1/26/2016 6 B. pertussis Ciliated cells of the respiratory system infected with Bordetella pertussis Cilium Pertussis (Whooping Cough) • Stage 1: catarrhal stage, like the common cold • Stage 2: paroxysmal stage, mucus accumulates, violent coughing, gasping for air • Stage 3: convalescence stage, may last for months • Infants do not cope with the cougg g hin and brain damage often occurs as a result • Prevented by DTaP vaccine • Treated with erythromycin or other macrolides; must occur before coughing starts Pertussis • Before vaccines, 6000 people died annuall i th U it d St t f lly in the United States from pertussis • Today the acellular pertussis vaccine (DTaP) is given CDC reported Pertussis cases in the US: 1922-2013 Pertussis component Whole cell heat Whole cell, heat-killed Pertussis component acellular