Advantages Elimination of toxic metabolites, thereby increasing the therapeutic index of the drug Avoidance of pharmacologically active metabolites that can lead to long-term effects; Elimination of drug interactions resulting from metabolite inhibition of enzymes Simplification of pharmacokinetic problems caused by multiple active speciesAdvantages • Elimination of toxic metabolites, thereby increasing the therapeutic index of the drug; • Avoidance of pharmacologically active metabolitesthat can lead to long-term effects; • Elimination of drug interactions resulting from metabolite inhibition of enzymes; • Simplification of pharmacokinetic problems caused by multiple active species