Feature It has a close structural similarity to the lead; It has a meta bolically sensitive moiety built into the lead structure The incorporated metabolically sensitive spot does not affect the overall physicochemical or steric properties of the lead compoundFeature • It has a close structural similarity to the lead; • It has a metabolically sensitive moiety built into the lead structure; • The incorporated metabolically sensitive spot does not affect the overall physicochemical or steric properties of the lead compound;