上泽通大学 Shanghai Jiao Tong University Example:Ergosterol inhibitors麦角 固醇抑制剂 In most fungi,ergosterol replaces the cholesterol found in higher eukaryotic cell membranes.真菌以麦 角固醇代替高等真核生物中的胆固醇. >Polyenes:can bind to ergosterol and disrupts membrane function,eventually cause membrane permeability and cell death.多烯烃 >Azoles and allylamines:selectively inhibit ergosterol biosynthesis and therefore have broad antifungal activity. 氨杂茂及丙烯胺 Shanghai Jiao Tong UniversityShanghai Jiao Tong University Example: Ergosterol inhibitors麦角 固醇抑制剂 In most fungi, ergosterol replaces the cholesterol found in higher eukaryotic cell membranes.真菌以麦 角固醇代替高等真核生物中的胆固醇.  Polyenes: can bind to ergosterol and disrupts membrane function, eventually cause membrane permeability and cell death.多烯烃  Azoles and allylamines: selectively inhibit ergosterol biosynthesis and therefore have broad antifungal activity. 氮杂茂及丙烯胺