Sites of action of some antifungal chemotherapeutic agents抗真菌药的作 用位点 Membrane functions: Cell wall synthesis: Polyenes bind to Polyoxins inhibit chitin synthesis ergosterol and disrupt Echinocandins inhibit glucan synthesis membrane integrity Ergosterol synthesis: Azoles and allylamines inhibit synthesis Nucleus Nucleic acid synthesis: Microtubule formation: 5-Fluorocytosine is a nucleotide Griseofulvin disrupts analog that inhibits nucleic microtubule aggregation acid synthesis during mitosis 2012 Pearson Education,Inc.Sites of action of some antifungal chemotherapeutic agents 抗真菌药的作 用位点