Uric acid can be further converted to allantoin allantoate urea or Nh4+ in various animals. The deficiency of adenosine deaminase causes the severe immunodeficiency disease in humans (it is likely the accumulated adenosine is converted to datP which inhibits the formation of all dNdps by ribonucleotide reductase) Overproduction of uric acid was revealed to cause gout(痛风) Allopurinol, an inhibitor of xanthine oxidase is used to treat gout• Uric acid can be further converted to allantoin, allantoate, urea or NH4+ in various animals. • The deficiency of adenosine deaminase causes the severe immunodeficiency disease in humans (it is likely the accumulated adenosine is converted to dATP, which inhibits the formation of all dNDPs by ribonucleotide reductase). • Overproduction of uric acid was revealed to cause gout (痛风). • Allopurinol, an inhibitor of xanthine oxidase, is used to treat gout