、核苷酸降解代谢 1. Uric acid is the excreted end product of purine catabolism in humans and many other animals For adenosine, the amino group is hydrolyzed before the ribose group is removed For guanosine, the amino group is hydrolyzed after the ribose group is removed Xanthine oxidase, having multiple cofactors (including an FAD, a Mo complex, four different Fe-s clusters), catalyzes the o2-dependent conversion of hypoxanthine to xanthine and xanthine to uric acid一、核苷酸降解代谢 1. Uric acid is the excreted end product of purine catabolism in humans and many other animals • For adenosine, the amino group is hydrolyzed before the ribose group is removed. • For guanosine, the amino group is hydrolyzed after the ribose group is removed. • Xanthine oxidase, having multiple cofactors (including an FAD, a Mo complex, four different Fe-S clusters), catalyzes the O2 -dependent conversion of hypoxanthine to xanthine and xanthine to uric acid