1/26/2016 Membrane Disrupting Exotoxins Three Main Types of Exotoxins Superantigens Pore- contents out Superantigens cause an intense immune response due to release of high levels of cytokines from host cells(T cells) -Cause symptoms of fever,nausea,vomiting diarrhea,shock,and death Genotoxins damage DNA causing mutations. disrupting cell division,and leading to cancer high marity Cytolne:a small protein released from human cells that regulates the immune response and may induce fever.pain,or T cell proliferation. Diseases Caused by Exotoxins Endotoxins located in the bacterial cell Lipid A portion of lipopolysaccharides(LPS) of gram-negative bacteria 121/26/2016 12 Membrane Disrupting Exotoxins Superantigens Three Main Types of Exotoxins Superantigens cause an intense immune response due to release of high levels of cytokines from host cells (T cells) – Cause symptoms of fever, nausea, vomiting, diarrhea, shock, and death Genotoxins damage DNA causing mutations damage DNA causing mutations, disrupting cell division, and leading to cancer Cytokine: a small protein released from human cells that regulates the immune response and may induce fever, pain, or T cell proliferation. Diseases Caused by Exotoxins Endotoxins located in the bacterial cell Lipid A portion of lipopolysaccharides (LPS) of gram-negative bacteria