世界著名天然有机化学家朱子清先生 关附甲素 20 e and 朱任 关白附子 Why So many Cor unds in nature have Biological Effects toHumas? nd hav 3 3 盐酸关附甲素注射液是中科院上海药物研究所和 中国药科大学共同研发的抗心律失常一类新药， 从中药关白附子的根块中提取分离得到的二萜类 生物碱。 关白附子 2005年8月获得国家一类新药证书 Guanfu-base A 朱任宏 关附甲素 刘静涵 N OH OAc AcO H H HO 1．Chu T．T．（朱子清）．Abbauversuche in der Brucin-Reihe． Liebigs Annalen der Chemie，1935（517）：290-294． 2 . Chu T．T．（朱子清），Chou T．Q．（赵承嘏）．Study of Gelsemine.I．J．Amer. Chem．Soc., 1940（62）：1955-1957． 3. Chou T．Q．（赵承嘏），Chu T．T．（朱子清）．Study of Gelsemine.Ⅱ．J．Amer．Chem．Soc., 1941（63）：827-828． 4. Chou T．Q．Chu T．T. The Preparation andProperties of Peimine and Peiminine．J．Amer．Chem．Soc., 1941（63）：2936-2938． 5. Chu T．T．Chou T．Q. Conversion of Peimine into Peiminine and Vice Versa．J．Amer．Chem．Soc., 1947（69）：1257． 世界著名天然有机化学家 朱子清 先生 Nature is considered as the chemical factory immense production of chemically diverse compounds. Through the Natural Selection process, natural products possess a unique and vast chemical diversity and have been evolved for optimal interactions with biological macromolecules. Owing to their diversity, target affinity, and specificity, natural products have demonstrated enormous potential as modulators of bio-molecular function, been an essential source for drug discovery, and provided design principles for combinatorial library development. Why So many Compounds in Nature Have Why So many Compounds in Nature Have Biological Effects to Humans?