Prion protein(PrP): from Prpc to PrPSc Same amino acid sequences but different structures Normalen prion Patogen prion Prpc (cellular prion protein Prpsc(scrapie prion protein Mainly a-helix 43%B-sheet and 30% a-helix Solub Insoluble Sensitive to protease K Resistant to protease k Has normal functions, not pathogenic PathogenicPrion protein (PrP): from PrPC to PrPSc PrPC (cellular prion protein) Mainly α-helix Soluble Sensitive to protease K Has normal functions, not pathogenic PrPSc (scrapie prion protein) 43% β- sheet and 30% α-helix Insoluble Resistant to protease K Pathogenic Same amino acid sequences but different structures