Prions aggregate extracellularly within the central nervous system to form plaques known as amyloid, which disrupt the normal tissue structure Strong resistance to autoclave, UV, regular disinfectants Standard autoclave(121C, 20 min does not inactivate it. Needs134°C,2hStrong resistance to autoclave, UV, regular disinfectants. Standard autoclave (121oC, 20 min) does not inactivate it. Needs 134oC, 2h Prions aggregate extracellularly within the central nervous system to form plaques known as amyloid, which disrupt the normal tissue structure