antigen.2]This enormous diversity of antibody parato on the antigen-binding fragments allows the immune system to recognize an equally wide variety of antigens.The large and diverse population of antibody paratope is generated by random recombination events of a set of gene segments that encode different antigen- mgs品9ps,6 ed byndomhothe8心.hcr binding sites (o nis recom national process that produces clonal antibody paratope diversity is call e of D,and one of J is chosen.These gene segments are then joined together using random genetic recombination to 一hen0peeL y that retains the antigen-spe Contents .4.1 Immunoglobulin domains .4.2 Heavy chain CDRs.FV.Fab and Fc regions .5 Function 5.3 Natural antibodies ·6 :品 .6.3 Somatic hypermutation and affinity maturation .6.6 Asymmetrical antibodies Os)