0 Systems Biology Glossary ● Systems biology:understanding of the function of a biological system-tissue,organ,or organism-as a whole Genomics-study of gene expression,protein and metabolite profiles Epigenomics-DNA methylation(cells turn genes on/off) Transcriptomics-mRNA profile(functional genomics;microarrays) Proteomics-cell proteins(proteome) Metabolomics-cellular metabolites(products of gene expression) Metabonomics-organismal metabolites;metabolic profiling Pharmacogenomics-drug effects at the gene expression level Toxicogenomics-toxicity at the gene expression level Bioinformatics-genomic data acquisition,analysis,interpretation OSU rgoSystems Biology Glossary • Systems biology: understanding of the function of a biological system–tissue, organ, or organism–as a whole. Genomics – study of gene expression, protein and metabolite profiles Epigenomics – DNA methylation (cells turn genes on/off) Transcriptomics – mRNA profile (functional genomics; microarrays) Proteomics – cell proteins (proteome) Metabolomics – cellular metabolites (products of gene expression) Metabonomics – organismal metabolites; metabolic profiling Pharmacogenomics – drug effects at the gene expression level Toxicogenomics – toxicity at the gene expression level Bioinformatics – genomic data acquisition, analysis, interpretation