Comparison of parasympathetic and sympathetic nervous system ACh Anatomic Aspects: ACh Medulla The parasympathetic preganglionic motor fibers originate in cranial nerve nuclei Ill,VIl,IX,and X and in sacral segments(S2-S4);cranioscral divisior .The sympathetic preganglionic fibers originate ACh in the thoracic(T1-T12)and lumbar(L1-L5); thoracolumbar division Spinal cord ACh .The preganglionic sympathetic fibers are short and the postganglionic fibers are long; ACh .The preganglionic parasympathetic fibers are Adrenal Epi,NE medulla longer and the postganglionic fibers are short. ACh Voluntary motor nerve (From Katzung BG,editor:Basic Clinical Pharmacology,10th ed. 9(From Katzung BG, editor: Basic & Clinical Pharmacology, 10th ed. ) Comparison of parasympathetic and sympathetic nervous system Anatomic Aspects: The parasympathetic preganglionic motor fibers originate in cranial nerve nuclei III, VII, IX, and X and in sacral segments (S2-S4); cranioscral division The sympathetic preganglionic fibers originate in the thoracic (T1-T12) and lumbar (L1-L5); thoracolumbar division The preganglionic sympathetic fibers are short and the postganglionic fibers are long; The preganglionic parasympathetic fibers are longer and the postganglionic fibers are short. 9