Primary complement deficiencies clinical manifestation Increased susceptibility to infections with systemic course-bacteremia+meningitis S.pneumoniae,S.pyogenes,H.influenzae (early components defect in opsonization) Neisseria meningitidis (defect in terminal components Autoimmune disorders defective immune complex clearance 。 Angioedema Primary complement deficiencies clinical manifestation • Increased susceptibility to infections with systemic course - bacteremia+meningitis • S. pneumoniae, S.pyogenes, H.influenzae (early components , defect in opsonization) • Neisseria meningitidis (defect in terminal components ) • Autoimmune disorders defective immune complex clearance • Angioedema