The Control of Activated CD4+T Cells by Regulatory T cell NKT cells/ CD4+CD25+cells CD4+CD25-cells Apoptosis peptide/APC L-12/ TH1 CD4+cells IFN-Y L-10 IL-4 IFN-Y Resting CD4 T cells Activated CD4 T cells TH2 CD4+cells Regulatory immunity CD4/CD8 interactions CD8 or CD4 CD8 or CD4 suppressor suppressor effector precursor L.Chess 2002 TH1 CD4+ cells TH2 CD4+ cells CD8 or CD4 suppressor precursor CD8 or CD4 suppressor effector Activated CD4 T cells peptide/APC Regulatory immunity CD4/CD8 interactions (- ) (- ) The Control of Activated CD4+ T Cells by Regulatory T cells Apoptosis Resting CD4 T cells IL-12/ IFN- IL-4 NKT cells/ CD4+CD25+ cells CD4+CD25- cells (- ) (- ) IL-10 IFN- L. Chess 2002