Condensation with Esters Loss of alkoxide ion results in nucleophilic acyl substitution. Step 1:Addition of the enolate Step 2:Elimination of the alkoxide RO enolate ester tetrahedral intermediate substitution product Copyright 2005 Pearson Prentice Hall,Inc. => Chapter 22 4Chapter 22 4 Condensation with Esters Loss of alkoxide ion results in nucleophilic acyl substitution. =>