Replication of DNA Both new strands are synthesized in the 53'direction They cannot be made in exactly the same way One strand must have its 3'end near the point of unraveling (the replication fork),while the other strand has its 5'end near the replication fork The complement of the original 5'3'strand is synthesized continuously in a single piece The compliment of the original 3'5'strand is synthesized discontinuously in small pieces that are often then linked by DNA ligasesBoth new strands are synthesized in the 5′→3′ direction ▪ They cannot be made in exactly the same way ▪ One strand must have its 3′ end near the point of unraveling (the replication fork), while the other strand has its 5′ end near the replication fork ▪ The complement of the original 5′→3′ strand is synthesized continuously in a single piece ▪ The compliment of the original 3′→5′ strand is synthesized discontinuously in small pieces that are often then linked by DNA ligases Replication of DNA