EPA Residential Risk Assessment Start with the NOAEL(mg/kg BW/day) Determine the uncertainty factors: Intraspecies(10X) Interspecies(10X) - Other(e.g.FQPA Safety Factor) Multiply uncertainty factors to determine target margin of Exposure(MOE). MOE 10 x10 x other UF OSU 0re9onsaEPA Residential Risk Assessment • Start with the NOAEL (mg/kg BW/day) • Determine the uncertainty factors: – Intraspecies (10X) – Interspecies (10X) – Other (e.g. FQPA Safety Factor) • Multiply uncertainty factors to determine target margin of Exposure (MOE). MOE = 10 x10 x other UF