The NEW ENGLAND JOURNAL f MEDICINE 2 名合超罗吕贷 分三黄日登生尽密昌云台名8 美喜 合云日的宝 华日吕的高司9为空会3名曾品的 pue 雕H N ENGLJ MED 356:24 WWW.NEJM.ORG JUNE 14.2007 use only.T h e n e w e ng l a nd j o u r na l o f m e dic i n e 2460 n engl j med 356;24 www.nejm.org june 14 , 2007 Table 1. Clinical Trials of Rosiglitazone in the Meta-Analysis.* Study and Reference Registry Number Phase Duration Rosiglitazone Group Control Group Drug No. of Patients Drug No. of Patients wk Trials included in original regis￾tration package 49653/0115-7 3 24 Rosiglitazone 357 Placebo 176 49653/0205,6 3 52 Rosiglitazone 391 Glyburide 207 49653/0245,6,8 3 26 Rosiglitazone 774 Placebo 185 49653/0935,6,9 3 26 Rosiglitazone with or without metformin 213 Metformin 109 49653/0945,6,9,10 3 26 Rosiglitazone and metformin 232 Metformin 116 Subtotal 1,967 793 Additional phase 2, 3, and 4 effi￾cacy trials 1006845 4 52 Rosiglitazone and glyburide 43 Glyburide 47 49653/1435 4 24 Rosiglitazone and glyburide 121 Glyburide 124 49653/2115 4 52 Rosiglitazone and usual care 110 Usual care 114 49653/2845,11 4 24 Rosiglitazone and metformin 382 Metformin 384 712753/0085 4 48 Rosiglitazone and metformin 284 Metformin 135 AVM1002645 NCT00359112 4 52 Rosiglitazone and metformin 294 Metformin and sulfonylurea† 302 BRL 49653C/1855 4 32 Rosiglitazone with or without metformin 563 Usual care with or without met￾formin 142 BRL 49653/3345 4 52 Rosiglitazone 278 Placebo 279 BRL 49653/3475 NCT00054782 4 24 Rosiglitazone and insulin 418 Insulin 212 49653/0155,12 3 24 Rosiglitazone and sulfonylurea‡ 395 Sulfonylurea‡ 198 49653/0795 3 26 Rosiglitazone with or without glyburide 203 Glyburide 106 49653/0805,13 3 156 Rosiglitazone 104 Glyburide 99 49653/0825,14 3 26 Rosiglitazone and insulin 212 Insulin 107 49653/0855 3 26 Rosiglitazone and insulin 138 Insulin 139 49653/0955 3 26 Rosiglitazone and insulin 196 Insulin 96 49653/0975 3 156 Rosiglitazone 122 Glyburide 120 The New England Journal of Medicine Downloaded from nejm.org on February 5, 2016. For personal use only. No other uses without permission. Copyright © 2007 Massachusetts Medical Society. All rights reserved