Reconstructed transcriptional regulatory network(Contd) iMH805/775 accounts for 805 genes and 775 regulatory interactions, and the network consists of the 750 metabolic genes in iND750 and 55 specific nutrient regulated transcription factors(tFs) The model allows 82 distinct intra-and extracellular metabolites to act as input signals to the regulatory network MMH805/775 also includes rules describing the mode of combinatorial control by different TFs at each promoter This logic-based representation allows in silico prediction of gene expression changes in response to environmental and genetic perturbations and integration of the regulatory network to the metabolic network model as described previous小Reconstructed transcriptional regulatory network (Cont’d) • iMH805/775 accounts for 805 genes and 775 regulatory interactions, and the network consists of the 750 metabolic genes in iND750 and 55 specific nutrient￾regulated transcription factors (TFs). • The model allows 82 distinct intra- and extracellular metabolites to act as input signals to the regulatory network. • iMH805/775 also includes rules describing the mode of combinatorial control by different TFs at each promoter. • This logic-based representation allows in silico prediction of gene expression changes in response to environmental and genetic perturbations and integration of the regulatory network to the metabolic network model as described previously