安徽医科大学国际教育学院教案与讲稿 Teaching Plan for International Students,AHMU Title of the course:Clinical Pharmacokinetics Chapter:One Teacher's name:Wu-Yi Sun Grade:2013 Department:School of International Education Time:14:30-16:50 Date(D/M/Y):3/9/2016 Lecture Notes: [Outline] 2min ·ADME factors Review of basic pharmacokinetic parameters Mathematical basis of clinical pharmacokinetics Effect of disease states on pharmacokinetics .Applications of clinical pharmacokinetics ·Study questions [Four Basic Processes in Pharmacokinetics] 3min Drug Administration (e.g..parenteral,oral.etc.) (from s into plasma) PLASMA Storage in Tissue Depot (e.g,body fat》 Bound Fre Drug Site of Action Excretion (e.g.kidney,expired air. sweat.feces) [Absorption of Drugs] 6min 1.Routes of Drug Administration Oral absorption:First-pass metabolism Sublingual absorption Parenteral:iv.,im.,sc. 2.Factors influencing absorption Related to Drugs:Water/lipid solubility,Molecular size,Degree of Ionization,Route of administration. Related to Body:pH,Blood flow to the absorption site,Total surface area available for absorption,Contact time at the absorption surface. 2安徽医科大学国际教育学院教案与讲稿 2 Teaching Plan for International Students, AHMU Title of the course: Clinical Pharmacokinetics Chapter: One Teacher’s name: Wu-Yi Sun Grade: 2013 Department: School of International Education Time: 14:30—16:50 Date (D/M/Y): 3/9/2016 Lecture Notes: [Outline] 2min
ADME factors
Review of basic pharmacokinetic parameters
Mathematical basis of clinical pharmacokinetics
Effect of disease states on pharmacokinetics
Applications of clinical pharmacokinetics
Study questions [Four Basic Processes in Pharmacokinetics] 3min [Absorption of Drugs] 6min 1. Routes of Drug Administration
Oral absorption: First - pass metabolism
Sublingual absorption
Parenteral: iv., im., sc. 2. Factors influencing absorption
Related to Drugs: Water/lipid solubility, Molecular size, Degree of Ionization, Route of administration.
Related to Body: pH, Blood flow to the absorption site, Total surface area available for absorption, Contact time at the absorption surface