安徽医科大学国际教育学院教案与讲稿 Teaching Plan for International Students,AHMU Title of the course:Clinical Pharmacokinetics Chapter:One Teacher's name: Wu-Yi Sun Grade:2013 Department:School of International Education Time:14:30-16:50 Date(D/M/Y):3/9/2016 1.Review fundamental pharmacokinetic principles. 2.Understand the pharmacokinetic processes of absorption, distribution Teaching metabolism,and excretion of drug substances,and how they may play a role in Objectives; dosage regimen design. Teaching 3.Recognize which physiologic processes and disease states may alter the Requirements pharmacokinetics of a particular drug. 4.Recognize which patient characteristics,disease states,and drug interactions must be considered when recommending initial or subsequent dosage regimens. 1.ADME factors 2.Review of basic pharmacokinetic parameters Teaching 3.Mathematical basis of clinical pharmacokinetics Content 4.Effect of disease states on pharmacokinetics 5.Applications of clinical pharmacokinetics Teaching Focus:How ADME may play a role in dosage regimen design. Teaching Difficult Problems:The physiologic processes and disease states may alter the Focus; pharmacokinetics of a particular drug. Difficult Problems Solutions:Give examples of renal and liver diseases affect the drug and their pharmacokinetics.The lectures are conducted using a case-based format which Solutions promotes an active-learning environment.Other teaching styles such as didactic lectures,question-answer sessions and class discussions are used as appropriate. ADME factors 33min Review of basic pharmacokinetic parameters 15min Time Mathematical basis of clinical pharmacokinetics 15min Allotment Effect of disease states on pharmacokinetics 30min Applications of clinical pharmacokinetics 20min Discussion 7min 1.The concept of first-pass metabolism,bioavailability,half-life Assignment 2.A patient is overdosed with salicylic acid,which is a weak acid.How do you treat this patient in order to remove the drug faster from his blood? 1.Principle of Clinical Pharmacology(Second Edition);ArthurJ.Atkinson Reference 2.Drug Discovery and Evaluation:Methods in Clinical Pharmacology.Vogel, H.Gerhard;Maas,Jochen;Gebauer,Alexander.2011 Text 3.Oxford Textbook of Clinical Pharmacology and Drug Therapy;David Grahame-Smith,Jeffrey Aronson Memo安徽医科大学国际教育学院教案与讲稿 1 Teaching Plan for International Students, AHMU Title of the course: Clinical Pharmacokinetics Chapter: One Teacher’s name: Wu-Yi Sun Grade: 2013 Department: School of International Education Time: 14:30—16:50 Date (D/M/Y): 3/9/2016 Teaching Objectives; Teaching Requirements 1. Review fundamental pharmacokinetic principles. 2. Understand the pharmacokinetic processes of absorption, distribution metabolism, and excretion of drug substances, and how they may play a role in dosage regimen design. 3. Recognize which physiologic processes and disease states may alter the pharmacokinetics of a particular drug. 4. Recognize which patient characteristics, disease states, and drug interactions must be considered when recommending initial or subsequent dosage regimens. Teaching Content 1. ADME factors 2. Review of basic pharmacokinetic parameters 3. Mathematical basis of clinical pharmacokinetics 4. Effect of disease states on pharmacokinetics 5. Applications of clinical pharmacokinetics Teaching Focus; Difficult Problems and their Solutions Teaching Focus: How ADME may play a role in dosage regimen design. Difficult Problems: The physiologic processes and disease states may alter the pharmacokinetics of a particular drug. Solutions: Give examples of renal and liver diseases affect the drug pharmacokinetics. The lectures are conducted using a case-based format which promotes an active-learning environment. Other teaching styles such as didactic lectures, question-answer sessions and class discussions are used as appropriate. Time Allotment ADME factors 33min Review of basic pharmacokinetic parameters 15min Mathematical basis of clinical pharmacokinetics 15min Effect of disease states on pharmacokinetics 30min Applications of clinical pharmacokinetics 20min Discussion 7min Assignment 1. The concept of first - pass metabolism, bioavailability, half-life. 2. A patient is overdosed with salicylic acid, which is a weak acid. How do you treat this patient in order to remove the drug faster from his blood? Reference Text 1. Principle of Clinical Pharmacology (Second Edition); ArthurJ. Atkinson 2. Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Vogel, H.Gerhard; Maas, Jochen; Gebauer, Alexander. 2011 3.Oxford Textbook of Clinical Pharmacology and Drug Therapy; David Grahame-Smith, Jeffrey Aronson Memo