Rule 5:Orientate the ① molecule such that the 9 lowest priority group is same as furthest away,then Observer consider the R configuration prioritization of the remaining 3 groups and determine if the arrangement is in a ② clockwise (R)or same as Observer anticlockwise (S) manner. S configurationRule 5 : Orientate the molecule such that the lowest priority group is furthest away, then consider the prioritization of the remaining 3 groups and determine if the arrangement is in a clockwise ( R ) or anticlockwise ( S ) manner