Cell adhesion ligand density effects on cell migration Cell migration on fibronectin coated substrates a,p, H-a91 Cells too strongly dherent to elease and extend filipodia Fibnnogen coating concentration (ug mr) Cells too weakly Lauffenburger adherent; no traction for mechanical forces Mean detachment force ( N Clustering effects DRAW ON BOARD: andom/individua 激激递 nign densIy ligand random/individual KrerEKmYm41( centration(top versus bottom) and the spatial distribution. from ogeneous to highly clustered (left to right), can be independentl Lecture 3- Biological Recognition 12 of 15ƒ Cell adhesion ligand density effects on cell migration16 Cell migration on fibronectin￾coated substrates: Cells too strongly adherent to release and extend filipodia Cells too weakly adherent; no traction for mechanical forces Lauffenburger lab ƒ Clustering effects DRAW ON BOARD: Lecture 3 – Biological Recognition 12 of 15