o PEO surface modified with PEO star polymers: CONTROL OF ARCHITECTURE FOR CONTROL OF LIGAND PRESENTATION (SLIDE) e Hbeonoctn Ligand density(RGD or FI Appeuximulely 140 cells Iro Utility of a branched polymer architecture self-assembled monolayers K L Prime and G M. Whitesides, J. An. Chem. Soc., 115, 10714 end-grafted polymers C G. Olander et al., in PolyY Ethylene Glycol) Chemistry Biotechnical and Biomedical Applicatio adsorbed polymers D Gingell and N Owens, J Biomed. Mat. Res, 28, 491(1994) plasma discharge coating G.P. Lopez et al., J. Biomed. Mat Res, 26(4), 415(1992) J. P. Bearinger. D G. Castner. S L. Gol A. Eranio. s Lecture 3- Biological Recognition 13 of 15o PEO surface modified with PEO star polymers: CONTROL OF ARCHITECTURE FOR CONTROL OF LIGAND PRESENTATION (SLIDE) ƒ Utility of a branched polymer architecture • self-assembled monolayers – K.L Prime and G.M. Whitesides , J. Am. Chem . Soc ., 115 , 10714 (1993) • end-grafted polymers – C.G. Golander et al., in Poly(Ethylene Glycol) Chemistry: Biotechnical and Biomedical Applications • adsorbed polymers – D. Gingell and N. Owens, J. Biomed . Mat. Res ., 28 , 491 (1994) • plasma discharge coating – G.P. Lopez et al., J. Biomed . Mat. Res., 26(4), 415 (1992) • hydrogels – J.P. Bearinger , D.G. Castner , S.L. Golledge , A. Rezanio , S. Hubchak , and K.E. Healy, Langmuir , 13, 5175 (1997) Lecture 3 – Biological Recognition 13 of 15