張星元:發酵原理電子講義附錄1 12 微生物生物工程基本理論的探索 張星元 (無鍚輕工大擊生物工程學院江蘇無鍚214036) 摘要∶工業發酵是微生物群體活動的動態過程。此過程靠如下三 種流動來維繫’即伴隨能量形式的轉換而發生的電子流動丶伴隨 異化和同化作用而發生的物質流動以及伴隨不同水平上的代謝調 節而發生的資訊流動。在分析以上三種流動的運行規律和工業發 酵大量資訊的基礎上’運用歸納邏輯的方法提岀了關於微生物生 物工程的三個基本假說·即生物能支撐假說丶代謝網路假說和細 胞經濟假說。如果這些假說成立’就有可能對工業發酵的微生物 代謝進行導向。從而形成由三個假說和三個推理組成的微生物生 物工程(工業發酵)基本理論 關鍵字∶生物能支撐假說∶代謝網路假說;細胞經濟假說;發酵 原理;代謝工程;微生物生物工程 Explorations of Basic Theory of Microbial Biotechnology Zhang X (School of Biotechnology, Wuxi University of Light Industry, Wuxi 214036, China Abstract Industrial fermentation is the processes in which microbial population functions. Those processes are supported and maintained by the three kinds of flows: o the electron flows which flows which operate along with dissimilation and assimilation, o the information flows which operate along with the metabolic regulations in different levels. On the basis of the analysis of the operation rule of above three kinds of flows and the generalization of a great deal of information of industrial fermentation, the three basic hypothesis of industrial fermentation(microbial biotechnology)are developed as follows: O the hypothesis of bioenergy support, O the hypothesis of metabolic network, o the hypothesis of cell economy. If those hypotheses are true, then the results of metabolic guidance for張星元：發酵原理電子講義 附錄 1-3 12 微生物生物工程基本理論的探索 張 星 元 （無錫輕工大學生物工程學院 江蘇無錫 214036） 摘要：工業發酵是微生物群體活動的動態過程。此過程靠如下三 種流動來維繫，即伴隨能量形式的轉換而發生的電子流動、伴隨 異化和同化作用而發生的物質流動以及伴隨不同水平上的代謝調 節而發生的資訊流動。在分析以上三種流動的運行規律和工業發 酵大量資訊的基礎上，運用歸納邏輯的方法提出了關於微生物生 物工程的三個基本假說，即生物能支撐假說、代謝網路假說和細 胞經濟假說。如果這些假說成立，就有可能對工業發酵的微生物 代謝進行導向。從而形成由三個假說和三個推理組成的微生物生 物工程（工業發酵）基本理論。 關鍵字：生物能支撐假說；代謝網路假說；細胞經濟假說；發酵 原理；代謝工程；微生物生物工程 Explorations of Basic Theory of Microbial Biotechnology Zhang Xingyuan (School of Biotechnology, Wuxi University of Light Industry, Wuxi 214036, China) Abstract ： Industrial fermentation is the processes in which microbial population functions. Those processes are supported and maintained by the three kinds of flows: ○1 the electron flows which operate along with energy-form transformation, ○2 the metabolite flows which operate along with dissimilation and assimilation, ○3 the information flows which operate along with the metabolic regulations in different levels. On the basis of the analysis of the operation rules of above three kinds of flows and the generalization of a great deal of information of industrial fermentation, the three basic hypothesis of industrial fermentation (microbial biotechnology) are developed as follows: ○1 the hypothesis of bioenergy support, ○2 the hypothesis of metabolic network, ○3 the hypothesis of cell economy. If those hypotheses are true, then the results of metabolic guidance for