Products of Mutated Genes Type of Antigen Examples of Human Tumor Antigens Products of mutated oncogene products:Ras mutations oncogenes (~10%of human carcinomas), p210 product of Bcr/Abl rearrangements(CmL) Tumor suppressor gene products: mutated p53(present in~50%of human tumors) Tumor antigens may be produced by randomly mutated genes whose products are not related to the malignant phenotype. Abnormally Expressed but Unmutated Cellular Proteins Type of Antigen Examples of Human Tumor Antigens HER2/neu(breast and other carcinomas Products of genes that are silent in most Cancer/testis antigens expressed in normal tissues expre normal nonone tenic proteins overexpressed in tumor cells hormaWopeegnmehngn Tyrosinase,gp100,MART in melanc Products of oncogenic viruses oeoon on antigens normally present in in prostate • Oncogenes and mutated tumor suppressor genes produce proteins that differ from normal cellular proteins and, therefore, can induce immune responses. Products of Mutated Genes Products of mutated oncogenes tumor suppressor genes Type of Antigen Examples of Human Tumor Antigens oncogene products: Ras mutations (∼10% of human carcinomas), p210 product of Bcr/Abl rearrangements (CmL) Tumor suppressor gene products: mutated p53 (present in ∼50% of human tumors) Tumor antigens may be produced by randomly mutated genes whose products are not related to the malignant phenotype. Abnormally Expressed but Unmutated Cellular Proteins HER2/neu (breast and other carcinomas) Type of Antigen Examples of Human Tumor Antigens unmutated but overexpressed products of oncogenes Products of genes that are silent in most normal tissues Cancer/testis antigens expressed in melanomas and many carcinomas; normally expressed mainly in the testis and placenta normal nononcogenic proteins overexpressed in tumor cells Tyrosinase, gp100, MART in melanomas (normally expressed in melanocytes) Products of oncogenic viruses Papillomavirus E6 and E7 proteins EBnA-1 protein of EBV Differentiation antigens normally present in tissue of origin Prostate-specific antigen in prostate carcinomas CD20 on B cell lymphomas