Cell adhesion molecules and their characteristics Family Location and/or Comments function recognized Integrins focal adhesions (E)fibronectin, relatively low hemi-desmosomes, collagen, laminin, affinities leukocyte immunoglobulins, (KD- 10-10 ("spreading") O actin filaments mol/liter) cell-matrix adhesion but also in some circulating cells and carbohydrates require Ca endothelial cells rolling " adhesion Ig superfamily mportant in Integrins, (immunoglobulin) homophilic desmosomes (actin flame RD Kamm 2003Cell adhesion molecules and their characteristics Family Location and/or Ligands Comments function recognized integrins focal adhesions, (E) fibronectin, relatively low hemi-desmosomes, leukocy te collagen, laminin, immunoglobulins, affinities (KD~ 10-6-10-8 ("spreading") (I) actin filaments mol/liter) adhesion, primarily cell-matrix adhesion but also in some cell-cell adhesions selectins circulating cells and carbohydrates require Ca 2+ endothelial cells, "rolling" adhesion Ig superfamily important in integrins, (immunoglobulin) cadherens immune response adherens junctions, homophillic (E) homophillic, require Ca 2+ desmosomes (I) actin filaments, intermediate filaments RD Kamm 2003