Factors affecting tolerance the role of host Factors that Favor immune Favor tolerance affect response response Age of responding >Fully differentiated; Newborn (mice),immuno- animal memory T&B cells logically immature Differentiation Older,immuno- Relative undifferentiated B state of cells logically mature cell with only IgM,T cells in the thymic cortexFactors affecting tolerance the role of host Factors that affect response Favor immune response Favor tolerance ➢ Age of responding animal ➢ Differentiation state of cells ➢ Fully differentiated; memory T & B cells ➢ Older, immuno￾logically mature ➢ Newborn (mice), immuno￾logically immature ➢ Relative undifferentiated B cell with only IgM, T cells in the thymic cortex