SHEN ET AL of ear ademic skill deficits.JChild Psychol Psychiatry commercial interests cepeg3a820gn0y.2o2o orm C REFERENCES Willcutt EG:The prevalence of DSM-IV . istence ofattention nemory un n-deficit 22. vad J.de Graaf R.et al:Childhood predictors of adul neity in ADHD:neu nd symptom domains 24 ella yond he 25. or and Psychiatry 2016:73:815-82s a-analysis.JAMA 26 27. 3020 Mol Psychi 20101b 9.Kofler MJ,Rap MD Sa iontime variabilityin Psychol Rev 2013 nnaire:a re 10. S,et al.H 12 RubiaktCdord on sus "hot" in condu de 59-e87 h MD. nts.Biol Psy y2017:82:6 14. DR,Seth S,Ma ib ah n ti ent in psychiatry yond the Med 204:4 .Goodman:Psych L98 Barke )Dalen L Remington B:Do utive deficits and 7- 37 ang-R.Chan RC 38.Due 17 Am JPsychiatry 1779.September 2020 and the European Union and royalties from Hogrefe, Kohlhammer, and Schattauer. Dr. Sahakian has served as a consultant for Cambridge Cognition and Peak. The other authors report no financial relationships with commercial interests. Received February 18, 2019; revision received February 17, 2020; accepted March 18, 2020; published online May 7, 2020. REFERENCES 1. Willcutt EG: The prevalence of DSM-IV attention-deficit/ hyperactivity disorder: a meta-analytic review. Neurotherapeutics 2012; 9:490–499 2. BarkleyRA, FischerM, Smallish L, et al: The persistence of attention￾deficit/hyperactivity disorder into young adulthood as a function of reporting source and definition of disorder. J Abnorm Psychol 2002; 111:279–289 3. Lara C, Fayyad J, de Graaf R, et al: Childhood predictors of adult attention-deficit/hyperactivity disorder: results from the World Health Organization World Mental Health Survey Initiative. Biol Psychiatry 2009; 65:46–54 4. Wåhlstedt C, Thorell LB, Bohlin G: Heterogeneity in ADHD: neu￾ropsychological pathways, comorbidity, and symptom domains. J Abnorm Child Psychol 2009; 37:551–564 5. Sonuga-Barke EJ: The dual pathway model of AD/HD: an elabo￾ration of neuro-developmental characteristics. Neurosci Biobehav Rev 2003; 27:593–604 6. Sonuga-Barke EJ: Causal models of attention-deficit/hyperactivity disorder: from common simple deficits to multiple developmental pathways. Biol Psychiatry 2005; 57:1231–1238 7. Sonuga-Barke EJS: Psychological heterogeneity in AD/HD: a dual pathway model of behaviour and cognition. Behav Brain Res 2002; 130:29–36 8. Martinussen R, Hayden J, Hogg-Johnson S, et al: A meta-analysis of working memory impairments in children with attention-deficit/ hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2005; 44:377–384 9. Kofler MJ, RapportMD, Sarver DE, et al: Reaction time variability in ADHD: a meta-analytic review of 319 studies. Clin Psychol Rev 2013; 33:795–811 10. Crosbie J, Arnold P, PatersonA, et al: Responseinhibition andADHD traits: correlates and heritability in a community sample. J Abnorm Child Psychol 2013; 41:497–507 11. Sonuga-Barke EJ, Taylor E, Sembi S, et al: Hyperactivity and delay aversion, I: the effect of delay on choice. J Child Psychol Psychiatry 1992; 33:387–398 12. Rubia K: “Cool” inferior frontostriatal dysfunction in attention-deficit/ hyperactivity disorder versus “hot” ventromedial orbitofrontal￾limbic dysfunction in conduct disorder: a review. Biol Psychiatry 2011; 69:e69–e87 13. Sonuga-Barke E, Bitsakou P, ThompsonM: Beyond the dual pathway model: evidence for the dissociation of timing, inhibitory, and delay￾related impairments in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2010; 49:345–355 14. Coghill DR, Seth S, Matthews K: A comprehensive assessment of memory, delay aversion, timing, inhibition, decision making, and variability in attention deficit hyperactivity disorder: advancing beyond the three-pathway models. Psychol Med 2014; 44: 1989–2001 15. Sonuga-Barke EJ, Dalen L, Remington B: Do executive deficits and delay aversion make independent contributions to preschool at￾tention-deficit/hyperactivity disorder symptoms? J Am Acad Child Adolesc Psychiatry 2003; 42:1335–1342 16. Yang B-R, Chan RC, Gracia N, et al: Cool and hot executive functions in medication-naive attention deficit hyperactivity disorder chil￾dren. Psychol Med 2011; 41:2593–2602 17. Thorell LB: Do delay aversion and executive function deficits make distinct contributions to the functional impact of ADHD symptoms? A study of early academic skill deficits. J Child Psychol Psychiatry 2007; 48:1061–1070 18. SolantoMV, Abikoff H, Sonuga-Barke E, et al: The ecological validity of delay aversion and response inhibition as measures of impulsivity in AD/HD: a supplement to the NIMH multimodal treatment study of AD/HD. J Abnorm Child Psychol 2001; 29:215–228 19. Patros CHG, L Sweeney K, Mahone EM, et al: Greater delay dis￾counting among girls, but not boys, with ADHD correlates with cognitive control. Child Neuropsychol 2018; 24:1026–1046 20. Karalunas SL, Huang-Pollock CL: Examining relationships between executive functioning and delay aversion in attention deficit hy￾peractivity disorder. J Clin Child Adolesc Psychol 2011; 40:837–847 21. Patros CHG, Alderson RM, Lea SE, et al: Visuospatial working memory underlies choice-impulsivity in boys with attention-deficit/ hyperactivity disorder. Res Dev Disabil 2015; 38:134–144 22. Bickel WK, Yi R, Landes RD, et al: Remember the future: working memory training decreases delay discounting among stimulant addicts. Biol Psychiatry 2011; 69:260–265 23. Wesley MJ, Bickel WK: Remember the future II: meta-analyses and functional overlap of working memory and delay discounting. Biol Psychiatry 2014; 75:435–448 24. Castellanos FX, Proal E: Large-scale brain systems in ADHD: beyond the prefrontal-striatal model. Trends Cogn Sci 2012; 16:17–26 25. Norman LJ, Carlisi C, Lukito S, et al: Structural and functional brain abnormalities in attention-deficit/hyperactivity disorder and obsessive-compulsive disorder: a comparative meta-analysis. JAMA Psychiatry 2016; 73:815–825 26. ThaparA: Discoveries on the genetics ofADHDin the 21st century: new findings and their implications. Am J Psychiatry 2018; 175:943–950 27. Meyer-Lindenberg A, Weinberger DR: Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci 2006; 7:818–827 28. Schumann G, Loth E, Banaschewski T, et al: The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology. Mol Psychiatry 2010; 15:1128–1139 29. Milham MP, Fair D, Mennes M, et al: a model to advance the translational potential of neuroimaging in clinical neuroscience. Front Syst Neurosci 2012; 6:62 30. Goodman R: The Strengths and Difficulties Questionnaire: a re￾search note. J Child Psychol Psychiatry 1997; 38:581–586 31. Albaugh MD, Hudziak JJ, Ing A, et al: White matter microstructure is associated with hyperactive/inattentive symptomatology and polygenic risk for attention-deficit/hyperactivity disorder in a population-based sample of adolescents. Neuropsychopharmacology 2019; 44:1597–1603 32. Albaugh MD, Ivanova M, Chaarani B, et al: Ventromedial prefrontal volume in adolescence predicts hyperactive/inattentive symptoms in adulthood. Cereb Cortex 2019; 29:1866–1874 33. Albaugh MD, Orr C, Chaarani B, et al: Inattention and reaction time variability are linked to ventromedial prefrontal volume in adoles￾cents. Biol Psychiatry 2017; 82:660–668 34. Bayard F, Nymberg Thunell C, Abé C, et al: Distinct brain structure and behavior related to ADHD and conduct disorder traits. Mol Psychiatry (Epub ahead of print, August 14, 2018) 35. Shrout PE: Measurement reliability and agreement in psychiatry. Stat Methods Med Res 1998; 7:301–317 36. Goodman R: Psychometric properties of the Strengths and Diffi- culties Questionnaire. J Am Acad Child Adolesc Psychiatry 2001; 40: 1337–1345 37. Kirby KN, Petry NM, Bickel WK: Heroin addicts have higher dis￾count rates for delayed rewards than non-drug-using controls. J Exp Psychol Gen 1999; 128:78–87 38. Duckworth AL, SeligmanME: Self-discipline outdoes IQ in predicting academic performance of adolescents. Psychol Sci 2005; 16:939–944 39. Sahakian BJ, Owen AM: Computerized assessment in neuropsy￾chiatry using CANTAB: discussion paper. J R Soc Med 1992; 85: 399–402 Am J Psychiatry 177:9, September 2020 ajp.psychiatryonline.org 853 SHEN ET AL