Lung parenchyma VON NEERGAARD EXPERIMEN Effect of Image removed due to liquid inflation copyright considerations Effect of of extension ension Relaxation pressure Mostly air, parenchyma mostly elastin and collagen. Proteoglycans(PGs)and glycosaminoglycanS (GAGs) a)GLYCOSAMINOGLYCANS (GAGs) form gels i) polysaccharide chains of disaccharide units i too inflexible and highly charged to fold in a compact way i strongly hydrophil iv) form extended conformations and gels v)osmotic swelling(charge repulsion) vi) usually make up less than 10% of ECM by weight vii)fill most of the ECM space vii) four main groups a hyaluronan b. chondroitin sulfate and dermatan sulfate C heparin sulfate and heparin d. keratin sulfateLung parenchyma Mostly air, parenchyma mostly elastin and collagen. Effect of collagen at high degrees of extension Mostly linear response at small extensions Effect of surface tension of gas￾liquid interface Proteoglycans (PGs) and glycosaminoglycans (GAGs) a) GLYCOSAMINOGLYCANS (GAGs) form gels i) polysaccharide chains of disaccharide units ii) too inflexible and highly charged to fold in a compact way iii) strongly hydrophilic iv) form extended conformations and gels v) osmotic swelling (charge repulsion) vi) usually make up less than 10% of ECM by weight vii) fill most of the ECM space viii) four main groups a. hyaluronan b. chondroitin sulfate and dermatin sulfate c. heparin sulfate and heparin d. keratin sulfate 11 Image removed due to copyright considerations Image removed due to copyright considerations