国生一 国上特 “ Preparation of semisolids Transdermal drug delivery ·Fusion method systems ·Emulsion method ·Cold incorporation 国生一 圈生 Transdermal drug delivery involves the application Difference between transdermal delivery and topical of a drug to the skin to achieve systemically active delivery levels of the drug to treat diseases remote from the application site. .Transdermal drug delivery involves the application of a drug to the skin to achieve systemically active levels of Transdermal drug delivery systems (TDDS) the drug to treat diseases remote from the application site. Transdermal therapeutic systems(TTS) Topical drug delivery is to deliver drugs to the local tissues directly under the application site or within tissues under and around the site of application. 国垫生 Worldwido Market for Transdermal Drug DeFvery Systems s700c 国Advantages of TDDS Escape hepatic first-pass effect s6a00 00. Sustained and controlled release s3,000 Minimize the fluctuation of blood level s2,00.0 .Improve patients'compliancy 0 00 Easy for applying and removing 66 Shanghai Jiao Tong University Preparation of semisolids • Fusion method • Emulsion method • Cold incorporation Transdermal drug delivery systems Shanghai Jiao Tong University Transdermal drug delivery involves the application of a drug to the skin to achieve systemically active levels of the drug to treat diseases remote from the application site. • Transdermal drug delivery systems (TDDS) • Transdermal therapeutic systems ( TTS) Shanghai Jiao Tong University Difference between transdermal delivery and topical delivery • Transdermal drug delivery involves the application of a drug to the skin to achieve systemically active levels of the drug to treat diseases remote from the application site. • Topical drug delivery is to deliver drugs to the local tissues directly under the application site or within tissues under and around the site of application. Shanghai Jiao Tong University Advantages of TDDS • Escape hepatic first-pass effect • Sustained and controlled release • Minimize the fluctuation of blood level • Improve patients’ compliancy • Easy for applying and removing Shanghai Jiao Tong University Worldwide Market for Transdermal Drug Delivery Systems $- $1,000.00 $2,000.00 $3,000.00 $4,000.00 $5,000.00 $6,000.00 $7,000.00 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 Year Manufacturer Revenue (in millions)