图上人生 国生 Common constituents of semisolids Common constituents of semisolids ·Oleaginous bases More raw materials are available for use on ·Hydrocarbon the skin than other dosage forms.It is due to -Vaselin -Paraffin and liquid paraffin the type of absorption barrier and physicochemical environment surrounding ·Esters类脂 -Wool fat absorption sites. -Beeswax and spermaceti ·Vegetable oil ·Dimethicones 国丝生一 圈上生 Common constituents of semisolids Common constituents of semisolids ·Emulsion base ·Water soluble bases -Stearic acid,paraffin,beewax,Stearyl PEGs having average molecular weight below alcohols,Liquid paraffin,vaselin, 600 are clear,colorless liquids;those with vegetable oil molecular weight above 1000 are waxlike ·Water with materials. -Water,glycerin,propylene glycol,sorbitol ·Emulsifiers -Soap,Sodium lauryl sulfate,Alcohols and esters,Polyesters.... 国坠生 圈生 Common constituents of semisolids Formulation design of semisolid ·Gelling agents Therapeutic stratification of the skin .Carbomer Physicochemical property of active Carboxymethylcellulose ingredient .Hydroxypropyl methylcellulose ·Property of base ·Tragacanth 55 Shanghai Jiao Tong University Common constituents of semisolids • More raw materials are available for use on the skin than other dosage forms. It is due to the type of absorption barrier and physicochemical environment surrounding absorption sites. Shanghai Jiao Tong University Common constituents of semisolids • Oleaginous bases • Hydrocarbon – Vaselin – Paraffin and liquid paraffin • Esters 类脂 – Wool fat – Beeswax and spermaceti • Vegetable oil • Dimethicones Shanghai Jiao Tong University Common constituents of semisolids • Emulsion base • Oil – Stearic acid, paraffin, beewax, Stearyl alcohols, Liquid paraffin, vaselin, vegetable oil • Water – Water, glycerin, propylene glycol, sorbitol • Emulsifiers – Soap, Sodium lauryl sulfate, Alcohols and esters, Polyesters…. Shanghai Jiao Tong University Common constituents of semisolids • Water soluble bases • PEGs having average molecular weight below 600 are clear, colorless liquids; those with molecular weight above 1000 are waxlike with materials. Shanghai Jiao Tong University Common constituents of semisolids • Gelling agents • Carbomer • Carboxymethylcellulose • Hydroxypropyl methylcellulose • Tragacanth Shanghai Jiao Tong University Formulation design of semisolid • Therapeutic stratification of the skin • Physicochemical property of active ingredient • Property of base