上游充通大￥ SHANGHAI JIAO TONG UNIVERSITY Multiple outcomes after DNA binding are possible 1.DNA-binding protein may catalyze a specific reaction on the DNA molecule (i.e.,transcription by RNA polymerase) 2.The binding event can block transcription(negative regulation)） 3.The binding event can activate transcription (positive regulation) CHEN FENG,School of Life Sciences and Biotech.CHEN FENG，School of Life Sciences and Biotech. 1. DNA-binding protein may catalyze a specific reaction on the DNA molecule (i.e., transcription by RNA polymerase) 2. The binding event can block transcription (negative regulation) 3. The binding event can activate transcription (positive regulation) Multiple outcomes after DNA binding are possible