2/16/2016 Virulence Factors Variety of genes are needed for Shigella 一Shiga toxin invasion and cell-cell movement Production of enterotoxin subverts the epi functions Shiga Toxin by Shigella in the small intestine leads to diarrhea that precedes G63 dysentery cuole rupture mRNA- tracellular replication -Cell to cell spreading IpaB/C/D/A Target cell IpgD/lpgE Type III secretior Mxi/SpaTTSS system secretes effector proteins ENTRY into the host cell INTRACELLULAR CELL TO CELL MOTILITY SPREAD IcsA IpaB/C Ipgc Mxi/Spa TTSS 2/16/2016 9 Virulence Factors Production of enterotoxin Shiga Toxin by Shigella in the small intestine leads to diarrhea that precedes dysentery Variety of genes are needed for Shigella invasion and cell-cell movement Type III secretion system secretes eff t t i s ffector proteins into the host cell