Pathogenesis Affects each tissue Accumulation of glycosaminoglycans(hyaluronic acid) Not to excessive synthesis t But decreased destrution Increased capillary permeability Interstitial edema Skin ◆正 eart muscle t Striated musclePathogenesis Affects each tissue Accumulation of glycosaminoglycans (hyaluronic acid)  Not to excessive synthesis  But decreased destrution Increased capillary permeability Interstitial edema  Skin  Heart muscle  Striated muscle