i.METABOLISMOF DRUGS TO TOXIC PRODUCTS ii.CLINICAL RELEVANCE OFDRUG METABOLISM a. Individual Differences b.Genetic Factors c.Diet Environmental Factors d Age Sex e.Drug-Drug Interactions During Metabolism f.Interactions Between Drugs Endogenous Compounds Section I Autonomic Drugs Introduction To Autonomic Pharmacology Total hours required 2 Total Classes required= Davs of Study Mon Period of Study Week 1&2-First semester Lecture 1 Class X Introduction to nervous system ii Anatomy of the autonomic nervous system a.Autonomic nervous system b.Somatic System iii. The anatomic classification of the autonomic system a.Parasympathetic Sympathetic iv.The classification of autonomic system based on the primary transmitter a.Cholinergic fibers b.Noradrenergic fibers(also c.non-adrenergic and non-cholinergic nerve v.The constitution of synapse a.Presynaptic membrane b.Svnaptic cleft c.Postsynaptic membrane vi.Neurotrasmitter chemistry system a.Cholinergic transmission b.Adrenergic transmission: vii.Autonomic receptors a.The classification of autonomic receptors(cholinoceptors. adrenoceptors) b.Locations of autonomic receptors: viii.Functional organization of autonomic activity i. METABOLISM OF DRUGS TO TOXIC PRODUCTS ii. CLINICAL RELEVANCE OFDRUG METABOLISM a. Individual Differences b. Genetic Factors c. Diet & Environmental Factors d. Age & Sex e. Drug-Drug Interactions During Metabolism f. Interactions Between Drugs & Endogenous Compounds Section II Autonomic Drugs Introduction To Autonomic Pharmacology Total hours required = 2 Total Classes required = 1 Days of Study = Mon Period of Study = Week 1&2 –First semester Lecture 1 Class X i. Introduction to nervous system ii. Anatomy of the autonomic nervous system a. Autonomic nervous system b. Somatic System iii. The anatomic classification of the autonomic System a. Parasympathetic b. Sympathetic iv. The classification of autonomic system based on the primary transmitter a.Cholinergic fibers b.Noradrenergic fibers(also c.non-adrenergic and non-cholinergic nerve v. The constitution of synapse a.Presynaptic membrane b.Synaptic cleft c.Postsynaptic membrane vi. Neurotrasmitter chemistry of the autonomic system a.Cholinergic transmission b.Adrenergic transmission: vii. Autonomic receptors a.The classification of autonomic receptors(cholinoceptors, adrenoceptors) b.Locations of autonomic receptors: viii. Functional organization of autonomic activity