Complement activation A system of plasma proteins that interact with Antigen/antibody complexes Pathogen surface motifs(alternative and lectin pathways Activation of complement results in Chemo-attraction of inflammatory cells Peptide mediators of inflammation (anaphylatoxins) Increased blood vessel permeability Smooth muscle contraction Mast cell degranulation Opsonization of pathogens(enhances phagocytosis) Killing of pathogens(membrane attack complex)Complement activation ◼ A system of plasma proteins that interact with ◼ Antigen/antibody complexes ◼ Pathogen surface motifs (alternative and lectin pathways ◼ Activation of complement results in ◼ Chemo-attraction of inflammatory cells ◼ Peptide mediators of inflammation (anaphylatoxins) ◼ Increased blood vessel permeability ◼ Smooth muscle contraction ◼ Mast cell degranulation ◼ Opsonization of pathogens (enhances phagocytosis) ◼ Killing of pathogens (membrane attack complex)