Acute HBV Infection with Progression to Chronic Infection: Typical serologic Course Acute Chronic (6 months) (Years) HBeAg Anti-HBe HBsAg Total anti-HBc IgM anti-HBc 0481216202428323652 Years Weeks after ExposureIgM anti-HBc Total anti-HBc HBsAg Acute (6 months) HBeAg Chronic (Years) Anti-HBe 0 4 8 12 16 20 24 28 32 36 52 Years Weeks after Exposure Acute HBV Infection with Progression to Chronic Infection: Typical Serologic Course